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目的:分析用硝苯地平缓释片联合依那普利治疗老年性高血压的临床疗效。方法:对2010年11月～2012年1月期间在我院进行治疗的56例老年性高血压患者的临床资料进行回顾性研究。我们将这56例患者随机分成治疗组和对照组,每组各有28例患者。两组患者均在进行常规治疗(包括进行运动、控制饮食、限制食盐的摄入量等,合并有糖尿病、血脂异常等疾病的患者继续服用降糖药、调脂药进行治疗)的基础上停用降压药2天。2天后,对照组患者服用硝苯地平缓释片进行治疗,治疗组患者在服用硝苯地平缓释片的基础上,加用依那普利进行治疗。治疗结束后,比较两组患者治疗的效果和用药的安全性。结果:治疗结束后,治疗组患者治疗的总有效率为96.5,对照组患者治疗的总有效率为82.1%。治疗组患者治疗的总有效率明显高于对照组患者,二者相比差异具有统计学意义(P<0.05)。经过治疗,治疗组患者血压下降的幅度明显大于对照组患者,二者相比差异具有统计学意义(P<0.05)。在治疗的过程中,治疗组患者的心率明显慢于对照组患者,二者相比差异具有统计学意义(P<0.05)。结论:用硝苯地平缓释片联合依那普利治疗老年性高血压疗效显著,副作用小,值得在临床上推广使用。
Objective: To analyze the clinical efficacy of nifedipine extended release tablets combined with enalapril in the treatment of senile hypertension. Methods: The clinical data of 56 elderly hypertensive patients treated in our hospital from November 2010 to January 2012 were retrospectively studied. We randomly divided these 56 patients into treatment and control groups, each with 28 patients in each group. Both groups were stopped on the basis of routine treatment (including exercise, diet control, restriction of salt intake, etc., patients with diabetes, dyslipidemia and the like continuing to take hypoglycemic agents and lipid-lowering drugs) Antihypertensive drugs with 2 days. Two days later, patients in the control group were treated with nifedipine sustained-release tablets. Patients in the treatment group were treated with enalapril on the basis of taking nifedipine sustained-release tablets. After treatment, the efficacy and medication safety of the two groups were compared. Results: At the end of treatment, the total effective rate of the treatment group was 96.5 and that of the control group was 82.1%. The total effective rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). After treatment, the treatment group patients with blood pressure decreased significantly larger than the control group, the difference between the two was statistically significant (P <0.05). During the course of treatment, the heart rate of the treatment group was significantly slower than that of the control group, the difference was statistically significant (P <0.05). Conclusion: Nifedipine sustained-release tablets combined with enalapril treatment of senile hypertension with significant side effects, it is worth in the clinical promotion.