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[目的]了解浙江省富硒地区人群的健康状况,初步掌握硒对人群健康的影响。[方法]采用生态对比研究的方法,在富硒与非富硒调查地区共选择322名成人居民作为研究对象,进行患病情况调查及实验检测分析。[结果]富硒调查地区2008年冠心病和脑卒中的发病率分别为6.23/10万、177.69/10万,均低于非富硒调查地区的19.74/10万和223.68/10万;富硒地区人群谷胱甘肽过氧化物酶平均水平为261.49U/L,明显高于非富硒地区的248.99U/L(t=2.64,P<0.05);富硒地区人群B淋巴细胞水平为9.33%,低于非富硒地区的11.18%(t=-4.00,P<0.05)。[结论]硒在减少心血管疾病患病率、抗肿瘤、免疫调节等方面具有重要作用。
[Objective] To understand the health condition of population in selenium-enriched area of Zhejiang Province and to grasp the influence of selenium on population health initially. [Method] With the method of ecological contrast study, a total of 322 adult residents were selected as study subjects in the selenium-enriched and non-selenium survey areas, and the prevalence survey and experimental test were conducted. [Results] The incidence rates of coronary heart disease and stroke in the selenium-enriched survey area in 2008 were 6.23 / 100,000 and 177.69 / 100,000, respectively, which were all lower than 19.74 / 100,000 and 223.68 / 100,000 in the non-Se-enriched survey areas; The average level of glutathione peroxidase in local population was 261.49U / L, which was significantly higher than 248.99U / L in non-selenium-enriched areas (t = 2.64, P <0.05). The level of B lymphocytes in selenium- %, Lower than 11.18% (t = -4.00, P <0.05) in non-selenium-rich areas. [Conclusion] Selenium plays an important role in reducing the prevalence of cardiovascular diseases, anti-tumor and immune regulation.