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目的探讨新诊断2型糖尿病患者强化血糖、血脂控制后对血清肠促胰素水平的影响。方法将本院收治的T2DM患者分为三组:A组:强化血糖控制组;B组:强化血脂控制组;C组:强化血糖、血脂控制组。所有T2DM患者在治疗前和经治疗后的第8周分别测量FPG、2 hPG、HbA1c、TC、TG、LDL-C、HDL-C、肠促胰素水平各一次,探讨肠促胰素与以上各指标的关系。结果①治疗8周后,与治疗前相比较,三组患者的肠促胰素GLP-1水平均有显著性升高(P<0.05),GIP水平无显著性变化;②治疗8周后,与治疗前相比较,A、C两组患者的空腹FPG、2 hPG、HbA1c水平均有显著性降低(P<0.01,P<0.001),B组无显著性变化;B、C两组患者的TC、TG、LDL-C、HDL-C水平均有显著性改善(P<0.05,P<0.01),A组患者的LDL-C、HDL-C水平有显著性改善(P<0.05),TC、TG水平无显著性变化。结论通过结果分析发现,肠促胰素GLP-1水平与空腹FPG、2 hPG、TC、TG、LDL-C水平呈负相关,与HDL-C水平呈正相关,临床考察肠促胰素水平变化情况,有助于准确诊疗T2DM患者血糖、血脂具体情况,便于临床更有效的治疗T2DM,可作为T2DM患者临床疗效评价的参考标准。
Objective To investigate the effects of intensive blood glucose and serum lipids on serum incretin levels in newly diagnosed type 2 diabetic patients. Methods T2DM patients admitted to our hospital were divided into three groups: group A: intensive glycemic control group; group B: intensive lipid control group; group C: intensive glucose and lipid control group. The levels of FPG, 2 hPG, HbA1c, TC, TG, LDL-C, HDL-C and incretin were measured in all T2DM patients before and after the treatment for the first 8 weeks. The relationship between the indicators. Results ① After 8 weeks of treatment, compared with those before treatment, the levels of GLP-1 in all three groups were significantly increased (P <0.05), but there was no significant change in GIP level. (8) After 8 weeks of treatment, Compared with those before treatment, fasting FPG, 2 hPG and HbA1c levels were significantly decreased in group A and group C (P <0.01, P <0.001), but no significant change in group B; Group B and group C The levels of TC, TG, LDL-C and HDL-C were significantly improved (P <0.05, P <0.01). The levels of LDL-C and HDL-C in group A were significantly improved , TG level no significant change. Conclusion Through the analysis of the results, it is found that the level of pancreatic hormone GLP-1 is negatively correlated with the levels of fasting FPG, 2 hPG, TC, TG, LDL-C and positively correlated with the level of HDL-C. , Help to accurately diagnose and treat T2DM patients with blood glucose, blood lipids specific conditions, to facilitate more effective clinical treatment of T2DM, T2DM can be used as a reference standard for clinical evaluation.