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目的 研制复方洛美沙星酊 ,观察其对中小面积Ⅰ～Ⅲ度烧烫伤治疗效果。方法 建立该制剂的质量控制标准 ;80例烧烫伤患者 ,随机单盲分为两组。A组 5 0例 ,年龄 9个月～ 6 2岁 ,用复方洛美沙星酊治疗 ,7天为 1疗程 ,连用 2～ 3个疗程。B组 30例 ,年龄 10个月～ 6 3岁 ,用 1%磺胺嘧啶银霜治疗 ,疗程同A组。观察其疗效及不良反应。结果 两组Ⅰ～Ⅱ度烧烫伤总有效率为 10 0 % ,Ⅲ度烧烫伤总有效率A组为 87.5 % ,B组为 80 %。两组疗效对比无显著差异 (P>0 .0 5 ) ,均无不良反应。结论 复方洛美沙星酊制备工艺简便 ,质量可控 ,临床治疗有独特疗效。
Objective To develop compound lomefloxacin tincture and observe its effect on the treatment of scalded burns of small and medium area Ⅰ ~ Ⅲ. Methods The quality control standard of the preparation was established. Eighty patients with burn and burn were randomly divided into two groups randomly. A group of 50 patients, aged 9 months to 62 years old, with compound lomefloxacin tincture treatment, 7 days for a course of treatment, once every 2 to 3 courses. Group B 30 patients, aged 10 months to 63 years old, with 1% sulfadiazine silver cream treatment, the same treatment with the A group. Observe its efficacy and adverse reactions. Results The total effective rate was 100% in Ⅰ ~ Ⅱ degree burn scalds in both groups. The total effective rate in Ⅲ degree burn scalds was 87.5% in group A and 80% in group B. No significant difference between the two groups (P> 0.05), no adverse reactions. Conclusion Lomefloxacin tincture preparation process is simple, quality control, clinical treatment has a unique effect.