论文部分内容阅读
胰岛素样生长因子-Ⅰ(insulin-like growth factor-Ⅰ,IGF-Ⅰ)是机体组织细胞增殖、分化和成熟过程中重要的细胞因子。IGF-Ⅰ生物学作用广泛,它不仅能模拟生长激素(growth hormone,GH)的某些生物学效应,同时也具有类似胰岛素的代谢活性,对多个器官组织有生物学功能。研究发现,IGF-Ⅰ与肝硬化患者或肝硬化鼠的肝功能、肾功能和营养状况等均有关。本文就IGF-Ⅰ及其与肝硬化的关系作一综述。
Insulin-like growth factor-I (IGF-I) is an important cytokine in the process of proliferation, differentiation and maturation of tissue cells. IGF-Ⅰ has a wide range of biological functions. It can not only simulate some biological effects of growth hormone (GH), but also has insulin-like metabolic activity and has biological functions on multiple organs and tissues. The study found that, IGF-Ⅰ liver cirrhosis patients with cirrhosis or liver function, renal function and nutritional status and so on. This article reviews the relationship between IGF-I and cirrhosis.