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本文应用兔疫组化方法研究慢性肝炎肝细胞坏死与乙型肝炎病毒(HBV)标志及T细胞亚群的关系,结果发现:e抗原阳性(eAg+)患者肝内HBsAg与HBcAg检出率明显高于e抗原阴性(eAg-)患者;在大多数膜HBsAg或浆膜型HBcAg表达部位中间或周围伴有肝细胞坏死,聚集在eAg+慢性活动型肝炎肝细胞坏死部位的单个核细胞大多为OKT~+_8细胞,OKT~+_4细胞少见,提示:eAg+的肝细胞破坏与HBV标志膜表达及OKT~+_8细胞浸润有一定关系。
In this study, the relationship between hepatitis B virus (HBV) markers and T cell subsets in chronic hepatitis was studied by using the method of immunohistochemistry. The results showed that the detection rate of HBsAg and HBcAg in liver was significantly higher in patients with e antigen positive (eAg +) In patients with e antigen negative (eAg-); most of the membrane HBsAg or serosal serotype HBcAg expression in the middle or around with hepatocellular necrosis, eagregation in hepatitis C eukaryotic necrosis of eAg + chronic monocytes most of the OKT ~ + _8 cells, OKT ~ + _4 cells rare, suggesting: eAg + destruction of liver cells and HBV markers membrane OKT ~ + _8 cell infiltration have a certain relationship.