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目的:探讨不同剂量尿激酶联合低分子肝素钙治疗急性心肌梗死的血清学观察(尿酸BNP Cys-C)。方法:收集2012年4月至2014年12月来我院就诊的急性心肌梗死患者300例,随机分为A、B、C三组,每组100例。A组给予小剂量尿激酶联合低分子肝素钙治疗,B组给予大剂量尿激酶联合低分子肝素钙治疗,C组给予单独低分子肝素钙治疗,观察各组患者预后差异。结果:A、B组治疗后患者血清尿酸、BNP及Cys-C水平均低于C组,上述差异分别经t检验或卡方检验两两比较,差异均有统计学意义(P<0.05),A、B两组之间无明显差异。结论:大、小剂量尿激酶联合低分子肝素钙治疗急性心肌梗死均可显著降低血清中尿酸、BNP及Cys-C水平。
Objective: To investigate the serum concentration of uric acid BNP Cys-C in patients with acute myocardial infarction treated with different doses of urokinase and low molecular weight heparin. Methods: A total of 300 acute myocardial infarction patients who came to our hospital from April 2012 to December 2014 were randomly divided into A, B and C groups of 100 cases. A group given low-dose urokinase combined with low-molecular-weight heparin treatment, B group given high-dose urokinase combined with low-molecular-weight heparin calcium, C group given low molecular weight heparin alone treatment, the difference was observed in each group of patients. Results: The levels of serum uric acid, BNP and Cys-C in group A and group B were lower than those in group C. The differences were statistically significant (P <0.05) by t-test or chi-square test. A, B no significant difference between the two groups. Conclusion: Both large and small doses of urokinase combined with low molecular weight heparin calcium can significantly reduce serum uric acid, BNP and Cys-C levels in patients with acute myocardial infarction.