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目的：探讨血浆中血栓素 Ｂ_２（ＴＸＢ_２），血小板α颗粒胰蛋白－１４０（ＧＭＰ－１４０）， ６－酮前列腺素１α（６－Ｋ－ＰＧＦ１α），内皮素（ＥＴ）、组织型纤溶酶原激活剂（ｔＰＡ）、纤溶酶原激活剂抑制物（ＰＡＩ）活性，在脑动脉硬化、脑血栓发病过程的作用及临床意义。方法：ＴＸＢ_２、Ｇｍｐ－１４０、６－Ｋ－ＰＧＦ１α、ＥＴ采用放射免疫法（ＲＩＡ）、ｔＰＡ、ＰＡＩ采用发色底物法分别测定脑动脉硬化，脑血栓和正常对照组的含量，并进行分析。结果：①脑动脉硬化组，脑血栓组血小板指标ＴＸＢ_２，ＧＭＰ－１４０水平明显高于正常组（Ｐ均＜０．０１）；②内皮细胞合成物６－Ｋ－ＰＧＦ１α、ＥＴ含量脑血栓组明显低于和高于正常组（Ｐ均＜０．０１），脑动脉硬化组无明显差异（Ｐ均＞０．０５）。 ③纤溶指标 ｔＰＡ， ｔＰＡ／ＰＡＩ两组脑血管病血浆水平明显低于正常组。 ＰＡＩ水平虽有增高，但无明显差异（Ｐ＞０．０５）。结论：脑血管疾病存在血小板活化，内皮细胞受损、纤溶活力低下，这些改变可能参与此二类疾病发病过程。故须针对以上改变对患者采用相应治疗措施。
Objective: To investigate the correlation between plasma TXB2, GMP-140, 6-K-PGF1α, endothelin (ET), tissue plasminogen activator The role of tPA and plasminogen activator inhibitor (PAI) in the pathogenesis of cerebral arteriosclerosis and cerebral thrombosis and its clinical significance. Methods: The levels of cerebral arteriosclerosis, cerebral thrombosis and normal control group were determined by radioimmunoassay (RIA), tPA and PAI using the chromogenic substrate method, and analyzed by TXB_2, GMP-140, 6-K-PGF1α and ET. . Results: ① The levels of TXB_2 and GMP-140 in cerebral arteriosclerosis group and cerebral thrombosis group were significantly higher than those in normal group (all P <0.01); ② The contents of 6-K-PGF1α and ET in endothelial cell were significantly higher in cerebral thrombosis group (P <0.01), no significant difference in cerebral arteriosclerosis group (all P> 0.05). ③ fibrinolysis index tPA, tPA / PAI two groups of cerebrovascular disease plasma levels were significantly lower than the normal group. Although PAI levels increased, but no significant difference (P> 0.05). Conclusion: Platelet activation, endothelial cell damage and fibrinolytic activity are low in cerebrovascular diseases. These changes may be involved in the pathogenesis of these two diseases. Therefore, the above changes should be taken for patients with appropriate treatment.