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目的:研究小牛血清去蛋白注射液联合常规治疗轻型缺血性卒中患者的临床疗效。方法:115例轻型缺血性卒中患者随机分为观察组58例和对照组57例。对照组予常规治疗,观察组在对照组基础上加用小牛血清去蛋白注射液,14 d为一疗程。比较两组美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin评分(m RS评分)、血液流变学指标变化,以及发病后90 d及1年卒中复发率,记录治疗过程中的药品不良反应。结果:治疗后,两组患者NIHSS评分和m RS评分均较治疗前显著改善(P<0.05),血液流变学各指标均较前显著降低(P<0.05);且观察组NIHSS评分和m RS评分,血浆黏度、全血黏度等均明显优于对照组(P<0.05)。观察组出院后1年卒中复发率为13.8%,明显低于对照组的31.6%(P<0.05)。治疗过程中两组均未见药品不良反应发生。结论:小牛血清去蛋白注射液联合常规治疗轻型缺血性卒中疗效好,可降低卒中复发率。
Objective: To study the clinical efficacy of deproteinised bovine serum in combination with routine treatment of patients with mild ischemic stroke. Methods: A total of 115 patients with mild ischemic stroke were randomly divided into observation group (58 cases) and control group (57 cases). The control group was given routine treatment. The observation group was treated with bovine serum albumin injection on the basis of the control group, 14 days for a course of treatment. The National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin score (mRS score), changes in hemorheology indices, and stroke recurrence rates at 90 days and 1 year after onset were compared between the two groups, and drugs in the course of treatment Adverse reactions. Results: After treatment, the NIHSS scores and mRSR scores of both groups were significantly improved (P <0.05), and the indexes of hemorheology were significantly lower than those before treatment (P <0.05). The NIHSS score and m RS score, plasma viscosity, whole blood viscosity, etc. were significantly better than the control group (P <0.05). The rate of recurrent stroke at 1 year after discharge in the observation group was 13.8%, which was significantly lower than that in the control group (31.6%, P <0.05). During the course of treatment, no adverse drug reaction occurred in both groups. Conclusion: Bovine serum deproteinization combined with conventional treatment of mild ischemic stroke is effective and can reduce the recurrence rate of stroke.