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目的:探讨梅尼埃病患者前庭诱发肌源性电位(VEMPs)的特征。方法:对22例单侧梅尼埃病以及21例正常对照者进行VEMPs测试,比较梅尼埃病患侧、健侧与对照组的VEMPs的引出率、潜伏期和振幅的差异。并将病例组按照纯音平均听阈(PTA)分为PTA≤40dBHL组和PTA>40dBHL组,比较2组的引出率。应用SPSS 19.0软件进行统计学分析。结果:病例组患侧与健侧的cVEMP、oVEMP的潜伏期与振幅均无差别。与对照组相比,病例组患侧cVEMP的N1潜伏期和P1潜伏期明显延长,N1-P1振幅显著减小,而oVEMP的N1-P1振幅也显著减小,但oVEMP的N1、P1潜伏期没有明显变化。并且PTA>40dBHL组的cVEMP引出率比PTA≤40dBHL组明显下降。结论:梅尼埃病患者双侧的cVEMP均引出率降低,P1、N1潜伏期延长,P1-N1振幅减小,oVEMP仅振幅减小,潜伏期没有变化。并且随着听力分期的升高,cVEMP引出率会下降。梅尼埃病患者的耳石器功能下降,尤其球囊明显。因此对梅尼埃病患者进行VEMPs检测,可以全面评估耳石器的功能状态。
Objective: To investigate the characteristics of vestibular evoked myogenic potential (VEMPs) in Meniere’s disease. Methods: VEMPs were measured in 22 cases of unilateral Meniere’s disease and 21 cases of normal controls. The differences in the lead-out rate, latency and amplitude of VEMPs in the ipsilateral, contralateral and control groups were compared. The cases were divided into PTA≤40dBHL group and PTA> 40dBHL group according to pure tone average hearing threshold (PTA). The extraction rate of the two groups was compared. SPSS 19.0 software was used for statistical analysis. Results: The latency and amplitude of cVEMP and oVEMP in the affected side and contralateral side of case group were not different. Compared with the control group, N1 latency and P1 latency of cVEMP in the affected group were significantly prolonged, amplitude of N1-P1 was significantly decreased, and amplitude of N1-P1 in oVEMP was also significantly decreased, while N1 and P1 latency of oVEMP did not change significantly . And the cVEMP lead-out rate of PTA> 40dBHL group was significantly lower than that of PTA≤40dBHL group. CONCLUSIONS: The incidence of cVEMP on both sides of Meniere’s disease decreased, the latency of P1 and N1 prolonged, the amplitude of P1-N1 decreased, the amplitude of oVEMP decreased only, and the latency did not change. And with the increase of hearing staging, cVEMP lead-out rate will decline. Ophthalmic function of Meniere’s patients decreased, especially in the balloon. Therefore, the detection of Meniere’s disease VEMPs, can fully assess the functional status of the otolith.