低氧引起肺动脉内皮细胞功能紊乱,可激活多种类型的氯通道,使氯离子外流,导致细胞膜去极化,最终引起肺动脉平滑肌收缩,产生肺动脉高压,而肺动脉高压又可引起右心室负荷增加,加重组织缺氧。所以肺动脉高压与急性肺损伤患者顽固性低氧血症有十分密切的关系,而氯通道在此过程中起一定作用。现综述氯离子通道的特点、生理作用及与急性肺损伤缺氧机制之间的关系。 Hypoxia causes pulmonary artery endothelial dysfunction, which can activate various types of chloride channels, causing chloride ions to flow out, resulting in depolarization of the cell membrane, eventually causing pulmonary artery smooth muscle contraction, resulting in pulmonary hypertension, which in turn can cause an increase in the right ventricular load, Increased tissue hypoxia. Therefore, pulmonary hypertension and acute lung injury patients with refractory hypoxemia have a very close relationship, and the chloride channel in the process play a role. Now summarize the characteristics of chloride ion channels, physiological role and the relationship between acute lung injury and hypoxia mechanism.