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为探讨抗高血压治疗后脑微血管损害的变化及其在预防脑卒中方面的意义,采用易卒中型肾血管性高血压大鼠(strokepronerenovascularhypertensiverats,RHRSP)72只,其中36只RHRSP在高血压稳定期开始用卡托普利加入饮用水中以抗高血压治疗,其余36只RHRSP为非治疗组,并以27只正常血压大鼠作为对照。结果发现治疗期间治疗组大鼠血压显著低于非治疗组,但仍高于正常;脑卒中发生率显著降低(分别为361%和66.7%,P<0.01),但未完全防止;脑内小动脉损害逆转不明显,而微动脉和毛细血管损害多数被阻止或逆转。本研究提示抗高血压治疗后脑微血管损害的逆转在高血压性脑卒中的预防方面起着重要作用。
In order to investigate the changes of cerebral microvascular damage after antihypertensive treatment and its significance in stroke prevention, 72 strokeoneurovascularhypertensiverats (RHRSP) were used, in which 36 RHRSP were stable in hypertension Beginning with captopril added to drinking water for antihypertensive treatment, the remaining 36 RHRSP non-treatment group, and 27 normal blood pressure rats as a control. The results showed that the blood pressure of the treatment group was significantly lower than that of the untreated group during treatment, but still higher than normal; the incidence of stroke was significantly lower (361% and 66.7%, respectively, P <0.01), but not Completely prevent; cerebral arteriolar lesions were not reversed significantly, while the majority of arteriolar and capillary damage were blocked or reversed. This study suggests that the reversal of brain microvascular damage after antihypertensive treatment may play an important role in the prevention of hypertension-induced stroke.