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[目的]通过研究不同锰暴露水平电焊工唾液锰和尿高香草酸水平的差异,探索职业性锰暴露的早期生物标志。[方法]选择青浦区24家锰电焊企业的234名电焊工人为暴露组,采用个体长时间采样采集工作场所空气锰,时间加权平均浓度(TWA)≥0.15 mg/m3者为高暴露组共121人,TWA<0.15 mg/m3者为低暴露组共113人,选取不接触锰工人135人为对照组,测定各组唾液锰和尿高香草酸浓度,分析各组间两指标的差异及其影响因素。[结果]暴露组和高暴露组唾液锰浓度分别为(7.65±5.57)μg/L和(13.38±15.36)μg/L,暴露组与对照组以及高暴露组与低暴露组比较,唾液锰浓度差异均有统计学意义(均P<0.01);高暴露组接锰工龄5年以上组唾液锰均值为(16.94±19.81)μg/L,较接锰工龄5年以下组差异有统计学意义(P<0.05);暴露组和高暴露组尿高香草酸浓度均值分别为(6.79±1.01)μg/L和(7.58±0.92)μg/L,暴露组与对照组以及高暴露组与低暴露组比较尿高香草酸差异有统计学意义(P<0.01)。[结论]唾液锰可以考虑作为职业性锰暴露的生物标志;尿高香草酸可以作为职业性锰暴露早期的效应标志。
[Objective] To explore the early biomarkers of occupational manganese exposure by studying the differences in saliva manganese and urine vanillic acid levels among different manganese exposure levels. [Method] A total of 234 welders from 24 manganese welding enterprises in Qingpu District were selected as the exposure group. Long-time sampling of air was used to collect airborne manganese in the workplace. The time-weighted average concentration (TWA) ≥ 0.15 mg / Person, TWA <0.15 mg / m3 for the low exposure group of 113 people, select the non-contact manganese workers 135 people as the control group, determination of saliva manganese and urinary vanillic acid concentrations in each group, analysis of the differences between the two groups and its impact factor. [Results] The concentrations of salivary manganese in exposed group and high exposed group were (7.65 ± 5.57) μg / L and (13.38 ± 15.36) μg / L, respectively. Compared with the control group and the high exposure group and the low exposure group, (All P <0.01). The average manganese content of saliva in the group with high exposure to manganese over 5 years was (16.94 ± 19.81) μg / L, which was significantly lower than that under the group of 5 years under manganese (6.79 ± 1.01) μg / L and (7.58 ± 0.92) μg / L, respectively. The exposure group and the control group, the high exposure group and the low exposure group The difference was statistically significant (P <0.01). [Conclusions] Salivary manganese can be considered as a biomarker of occupational manganese exposure. Urinary vanillic acid can be used as an early effect indicator of occupational manganese exposure.