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目的:探讨中西医结合疗法治疗小儿性早熟的临床价值。方法:将88例小儿性早熟女性患儿随机分为两组。对照组40例,给予甲地孕酮片治疗,实验组48例,在对照组基础上加用知柏地黄丸治疗。两组于治疗前后分别进行第二性征、生长速率、X射线骨龄的测定、子宫卵巢容积测定以及黄体生成素释放激素(LHRH)激发实验。结果:两组患儿经2年治疗后,均有第二性征减退、子宫卵巢回缩、血LH峰值下降等疗效(P<0.05);实验组各项指标优于对照组(P<0.05)。实验组骨龄差/年龄差比值较治疗前显著下降,对照组无显著变化。结论:知柏地黄丸联合甲地孕酮疗法可显著减慢患儿生殖器官发育,并可延缓骨龄成熟,提示采用中西医结合治疗小儿性早熟疗效满意,且可降低治疗费用,减轻患者经济负担。
Objective: To explore the clinical value of integrated traditional Chinese and western medicine in the treatment of precocious puberty in children. Methods: 88 cases of precocious puberty children were randomly divided into two groups. Control group of 40 cases, given megestrol tablets treatment, 48 cases in the experimental group, on the basis of the control group plus Zhibai Di Huang Wan treatment. Before and after treatment, the two groups were measured the second sexual characteristics, the growth rate, the X-ray bone age determination, the uterine ovary volume determination and the LHRH provocation test. Results: After 2 years of treatment, both groups had decreased secondary sexual characteristics, uterine ovary retraction and decreased blood LH level (P <0.05). The indexes in the experimental group were better than those in the control group (P <0.05 ). The ratio of skeletal age / age difference in experimental group decreased significantly compared with that before treatment, but there was no significant change in control group. Conclusion: Zhibai Di Huang Wan combined with megestrol therapy can significantly slow down the reproductive organs in children, and can delay the maturity of bone, suggesting the use of traditional Chinese and Western medicine treatment of precocious puberty in children with satisfactory results, and can reduce the cost of treatment and reduce the financial burden on patients .