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目的探讨原发性三叉神经痛的发病机制、无水酒精注射治疗的疗效及复发因素。方法对运用无水酒精注射治疗原发性三叉神经痛245例的临床资料及治疗经过进行了观察和分析。结果245例原发性三叉神经痛患者经无水酒精注射治疗后,疼痛消失165例,疼痛减轻80例,近期总有效率100.00%。随访有44例复发,其中6￣12个月复发16例,1、2a复发21例。2a以上7例,总复发率为17.96%。结论原发性三叉神经痛的可能发病机制有中枢病因学说、周围病因学说、免疫、生化等因素;无水酒精注射治疗原发性三叉神经痛,创伤小,疗效肯定,复发率低;神经纤维的再生或神经远端功能并非完全丧失、神经孔数目的变异及交通支的存在等是无水酒精注射治疗原发性三叉神经痛的复发因素。
Objective To investigate the pathogenesis of primary trigeminal neuralgia and the therapeutic effect and relapse factors of anhydrous alcohol injection. Methods Clinical data and treatment of 245 cases of primary trigeminal neuralgia treated with anhydrous alcohol injection were observed and analyzed. Results 245 cases of primary trigeminal neuralgia patients treated with anhydrous alcohol injection, the pain disappeared in 165 cases, 80 cases of pain relief, the recent total efficiency of 100.00%. Follow-up of 44 cases of recurrence, of which 6 to 12 months recurrence in 16 cases, 1,2 a recurrence in 21 cases. More than 2a in 7 cases, the total recurrence rate was 17.96%. Conclusion The possible pathogenesis of primary trigeminal neuralgia is central etiology, peripheral etiology, immunity, biochemistry and other factors; anhydrous alcohol injection for the treatment of primary trigeminal neuralgia, trauma, efficacy is positive, the recurrence rate is low; nerve fibers Of the regeneration or distal function of the nerve is not completely lost, the number of neural holes and the existence of the existence of traffic branch is the injection of anhydrous alcohol treatment of recurrent trigeminal neuralgia recurrence factor.