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儿茶酚胺类药品肾上腺素、去甲肾上腺素、异丙肾上腺素等,是临床预防和治疗各类低血压性疾患、抢救休克病人的必备药品。配制针剂一般加0.1～0.2％的焦亚硫酸钠作抗氧剂。我们工作中发现,市售样品贮存二年左右,有效含量降至90％以下,贮存十年的去甲肾上腺素注射液,可降至60％左右。含量下降主要是形成磺酸化合物。因此,现行处方不适应药品贮备要求。为此,我们对四种抗氧剂进行筛选;按拉丁方设计法重点对焦亚硫酸钠
Catecholamines epinephrine, norepinephrine, isoproterenol, etc., is the clinical prevention and treatment of various types of low blood pressure disorders, rescue patients with essential drugs shock. Preparation of injection generally add 0.1 ~ 0.2% sodium metabisulfite as antioxidant. Our work found that commercial samples stored for about two years, the effective content dropped below 90%, 10-year storage of norepinephrine injection can be reduced to about 60%. The decrease is mainly the formation of sulfonic acid compounds. Therefore, the current prescription does not meet the requirements of drug storage. To this end, we have four kinds of antioxidants to be screened; according to Latin square design focus on sodium metabisulfite