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目的:探讨宫颈癌分子机制和特定标记物及与宫颈癌相关的信号通路,能有效地预防和治疗宫颈癌并改善预后。方法:本研究采用人寡核苷酸芯片筛选维吾尔族宫颈癌与正常宫颈差异表达基因,并进行基因本体论分析及KEGG信号通路分析。结果:与正常宫颈相比,共筛选到新疆维吾尔族宫颈癌中差异表达基因2 758个,其中上调基因1326个,下调基因1432个,分属不同的通路。结论:宫颈癌的发生需要多基因的参与,m TOR信号通路、Hedgehog信号通路和Toll样受体信号通路与宫颈癌发生有关。
Objective: To explore the molecular mechanism of cervical cancer and specific markers and cervical cancer-related signaling pathways, which can effectively prevent and treat cervical cancer and improve prognosis. Methods: In this study, human oligonucleotide microarray was used to screen differentially expressed genes in Uigur cervical cancer and normal cervical tissues. Gene ontology and KEGG signal pathways were used to analyze the differences. Results: Compared with normal cervix, a total of 2 758 differentially expressed genes were detected in Uygur cervical cancer in Xinjiang, including 1326 up-regulated genes and 1432 down-regulated genes, belonging to different pathways. Conclusion: The multi-genes involved in the occurrence of cervical cancer are related to m TOR signaling pathway, Hedgehog signaling pathway and Toll-like receptor signaling pathway.