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目的:观察三叶因子I(Trefoilfactor1,TFF1)、三叶因子II(Trefoilfactor2,TFF2)在胃癌前病变(不典型增生和肠上皮化生)及胃癌的表达,探讨TFF1、TFF2表达与胃癌发生的关系。方法:对正常胃粘膜、胃粘膜肠上皮化生、胃癌组织各30例,采用SP免疫组化方法进行TFF1、TFF2蛋白的定位和半定量检测。结果:正常胃粘膜→肠上皮化生→不典型增生→胃癌四种病变中,TFF1、TFF2表达呈逐渐减弱趋势,差异具有显著性(P<0.05)。结论:TFF1、TFF2蛋白表达在胃癌发生过程中进行性下调,TFF1、TFF2蛋白表达可作为胃癌生物学行为的客观指标。
Objective: To observe the expression of Trefoilfactor1 (TFF1) and Trefoil factor 2 (TFF2) in gastric precancerous lesions (dysplasia and intestinal metaplasia) and gastric cancer, and to investigate the relationship between the expression of TFF1 and TFF2 and the occurrence of gastric cancer relationship. Methods: The normal gastric mucosa, gastric mucosal intestinal metaplasia and gastric cancer tissue were treated with SP immunohistochemical method for the localization and semi-quantitative detection of TFF1 and TFF2 protein. Results: The expressions of TFF1 and TFF2 gradually decreased in normal gastric mucosa → intestinal metaplasia → dysplasia → gastric cancer, the difference was significant (P <0.05). CONCLUSION: TFF1 and TFF2 protein expressions are down-regulated during gastric carcinogenesis. The expression of TFF1 and TFF2 protein may be used as objective indicators of biological behavior of gastric cancer.