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目的:探讨激素联合丙种球蛋白治疗小儿重症肌无力的临床疗效及对患儿免疫球蛋白和补体的影响。方法:回顾性分析在我院治疗的70例重症肌无力患儿的临床资料,采用随机序号的方式将其分为观察组和对照组各35例,观察组给予甲泼尼龙联合丙种球蛋白,对照组仅给予甲泼尼龙,观察两组的临床疗效及免疫球蛋白和补体变化情况。结果:观察组总有效率为94.3%明显优于对照组74.3%,两组比较有统计学意义(P<0.05);观察组症状明显缓解时间(6.55±1.35)d以及总住院天数(17.15±3.65)d较对照组明显缩短,两组比较差异均有统计学意义(P<0.05)。结论:采用激素联合丙种球蛋白治疗小儿重症肌无力,可以明显改善患者肌无力症状,获得较为满意的临床疗效,值得进一步推广使用。
Objective: To investigate the clinical efficacy of hormones combined with gamma globulin in the treatment of pediatric myasthenia gravis and its effect on immunoglobulin and complement in children. Methods: The clinical data of 70 patients with myasthenia gravis treated in our hospital were retrospectively analyzed. The patients were divided into observation group (35 cases) and control group (35 cases) by random number. The observation group was given methylprednisolone combined with gamma globulin, The control group was given only methylprednisolone, the clinical efficacy and the changes of immunoglobulin and complement in the two groups were observed. Results: The total effective rate of the observation group was 94.3%, which was significantly better than that of the control group (74.3%), the two groups were statistically significant (P <0.05); the symptom relief time (6.55 ± 1.35) d and total hospitalization days 3.65) d than the control group was significantly shorter, the difference between the two groups were statistically significant (P <0.05). Conclusion: Hormone combined with gamma globulin in the treatment of pediatric myasthenia gravis, can significantly improve the symptoms of patients with myasthenia gravis, to obtain more satisfactory clinical efficacy, it is worth further promotion.