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目的:探讨血清胆红素浓度与四种动脉粥样硬化( AS)性疾病的关系。方法:观察组分为四组,单纯性高血压组、冠心病组、糖尿病组、脑梗死组,对照组为同年龄段健康查体者,检测空腹血清总胆红素、直接胆红素、总胆固醇、三酰甘油、高密度脂蛋白胆固醇,低密度脂蛋白胆固醇,计算间接胆红素,并对检测结果进行统计学分析。结果:与对照组比较,观察组中直接胆红素均有所下降,但差异无显著统计学意义( P>0 .0 5 ) ,总胆红素与间接胆红素除脑梗死组外,其他各组均明显降低( P<0 .0 5 ) ;除脑梗死组HDL - C与对照组无显著差异外,其他观察组血脂各指标与对照组比较均有显著统计学差异( P<0 .0 5 ) ,且糖尿病组三酰甘油及冠心病组低密度脂蛋白胆固醇与对照组比较有极显著统计学差异( P<0 .0 1 )。结论:高血压、冠心病、脑梗死、糖尿病等动脉粥样硬化相关性疾病血清胆红素浓度有不同程度降低,其中,间接胆红素降低更明显,提示可将胆红素水平作为AS患者体内氧化活性增加的一个临床监测指标
Objective: To investigate the relationship between serum bilirubin concentration and four kinds of atherosclerosis (AS) diseases. Methods: The observation group consisted of four groups: simple hypertensive group, coronary heart disease group, diabetes mellitus group, cerebral infarction group and control group, all of whom were in the same age group. The levels of serum total bilirubin, direct bilirubin, Total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, calculate indirect bilirubin, and test results were statistically analyzed. Results: Compared with the control group, the direct bilirubin in observation group decreased, but the difference was not statistically significant (P> 0.05), total bilirubin and indirect bilirubin in addition to cerebral infarction group, (P <0.05). There was no significant difference between HDL - C and control group except for cerebral infarction group (P <0. 05) .0 5), and there was a significant difference between low-density lipoprotein cholesterol and triglyceride and coronary heart disease in diabetic group (P <0.01). Conclusion: Serum bilirubin levels in patients with atherosclerosis-related diseases such as hypertension, coronary heart disease, cerebral infarction and diabetes are decreased to some extent. Among them, the decrease of indirect bilirubin is more obvious, suggesting that bilirubin levels can be used as a marker of AS A clinical indicator of increased oxidative activity in the body