Objective: To analyze the genotypes of CCR5 △ 32,CCR2b-64I and SDF 1-3`A and mutation frequencies of allelic genes in Chinese populations infected with HIV-1.Methods: Genome DNA from peripheral blood mononuclear cells (PBMCs) of 78 HIV-1 infectors was amplified by polymerase chain reaction (PCR). CCR5, CCR2b and SDF1 gene fragments were obtained from restrictive fragment length polymorphism (RFLP) and/or CCR/△32, CCR5m303,CCR2b-64I and SDF1-3’ A allelic genes’ mutational frequencies were sequenced directly from PCR products.Results: None of CCR5△32, CCR5m303 gene mutation were found in 78 subjects with HIV-1 infection. The allelic gene mutation frequencies of CCR2b-64I and SDF1-3’A corresponding to 14.9-34.0% and 17.6-38.2% of 95% CI, were 22.79% and 26.92% respectively. Their colony distribution conformed to the Hardy-Weinberg equilibrium.Conclusion: The HIV-1 infections found at present are all susceptible population of CCR5△32 and CCR5m303. The polymorphism and frequencies of CCR5△32, CCR5m303,CCR2b-64I and SDFI-3’A alleles from Chinese HIV-1 infected population were disclosed in this study for the first time, which is of significance for studying the genetic resistance to susceptibility to HIV-1 infection as well as AIDS disease progression.