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目的 探讨老年慢性呼吸衰竭患者血小板活化因子 (PAF)及血小板粘附、聚集、释放功能的改变及与老年慢性肺心病和呼吸衰竭发展的关系。 方法 生物定量法观察老年慢性呼吸衰竭组患者 (5 5例 )、老年健康人组 (40例 )及非老年健康人组 (35例 )血小板激活因子 (PAF)的改变 ,放免法观察血小板膜 GMP140、血小板释放功能、血小板粘附功能 (PADT)和血小板聚集功能 (PAg T)的变化。 结果 老年慢性呼吸衰竭组 PAF为 (171± 5 1) nm ol/ L 高于老年健康人的 (132± 40 ) nmol/ L(P<0 .0 1) ,老年健康人组也显著高于非老年健康人组 (P<0 .0 5 )。老年慢性呼吸衰竭患者 PADT、PAg T明显高于老年健康人组 (P<0 .0 1)及非老年健康人组 (P<0 .0 1)。老年慢性呼吸衰竭患者血小板膜 GMP140为 (4813± 180 8)分子数 /血小板 ,显著高于老年健康人组 (P<0 .0 1)及非老年健康人组 (P<0 .0 1)。 结论 慢性呼吸衰竭患者中 PAF产生和释放增加促使血小板功能亢进 ,进一步引起微血栓形成及肺循环障碍 ,促进老年慢性肺心病及呼吸衰竭的发展。
Objective To investigate the relationship between platelet activating factor (PAF), platelet adhesion, aggregation and release in senile patients with chronic respiratory failure and its relationship with chronic pulmonary heart disease and respiratory failure. Methods The changes of platelet activating factor (PAF) in elderly patients with chronic respiratory failure (55 cases), elderly healthy people (40 cases) and non-elderly healthy people (35 cases) were observed by bioassay. The levels of platelet membrane GMP140 , Platelet release function, platelet adhesion function (PADT) and platelet aggregation function (PAg T) changes. Results The PAF in senile chronic respiratory failure group was (171 ± 5 1) nm ol / L higher than that in elderly healthy people (132 ± 40) nmol / L (P <0.01) Elderly healthy group (P <0.05). PADT and PAg T in elderly patients with chronic respiratory failure were significantly higher than those in healthy elderly (P <0.01) and non-elderly healthy subjects (P <0.01). Platelet membrane GMP140 in aged patients with chronic respiratory failure was (4813 ± 180 8) molecules / platelet, which was significantly higher than that of the elderly healthy people (P <0.01) and the non-elderly healthy people (P <0.01). Conclusions Increased production and release of PAF in patients with chronic respiratory failure may promote platelet function and further cause microthrombus formation and pulmonary circulation disorder and promote the development of senile chronic pulmonary heart disease and respiratory failure.