目的观察芪附龙葵汤治疗转移性结直肠癌患者的疗效。方法将59例转移性结直肠癌患者随机分为治疗组30例和对照组29例,对照组给予Xelox方案化疗;治疗组在对照组的基础上服用芪附龙葵汤,每日1剂。两组均21天为1个疗程,共治疗4个疗程。比较两组患者的近期疗效、生存质量及毒副反应。结果治疗组近期疗效总有效率为63.3%,对照组为34.5%,治疗组优于对照组(P<0.05)。治疗组生存质量上升+稳定为26例占86.7%,对照组上升+稳定为16例占55.2%,治疗组优于对照组(P<0.05)。两组患者发生毒副反应比较:治疗组骨髓抑制8例占26.7%、外周神经毒性9例占30.%、胃肠道反应7例占23.3%;对照组分别为12例占41.4%、16例占55.2%及16例占55.2%。两组胃肠道反应比较,治疗组优于对照组(P<0.05)。结论芪附龙葵汤联合Xelox方案治疗转移性结直肠癌有较好的临床疗效,能提高患者生存质量,减轻化疗毒副反应。 Objective To observe the curative effect of QifangLongKuiTang on patients with metastatic colorectal cancer. Methods Fifty-nine patients with metastatic colorectal cancer were randomly divided into treatment group (n = 30) and control group (n = 29). The control group was treated with Xelox regimen. The treatment group was given Qixinkang Kui Tang on the basis of the control group. Both groups were 21 days for a course of treatment, a total of 4 courses of treatment. The curative effect, quality of life and toxicity were compared between the two groups. Results The total effective rate of the treatment group was 63.3%, while that of the control group was 34.5%. The treatment group was better than the control group (P <0.05). In the treatment group, the quality of life increased + stabilized in 26 cases (86.7%), in control group (55.2% in 16 cases). The treatment group was superior to the control group (P <0.05). There were 8 cases of bone marrow suppression in treatment group, accounting for 26.7%, 30% of peripheral neurotoxicity, 7 cases of gastrointestinal reaction in 23.3%, 12 cases in control group, accounting for 41.4%, 16 Cases accounted for 55.2% and 16 cases accounted for 55.2%. The two groups of gastrointestinal reactions, the treatment group was better than the control group (P <0.05). Conclusion Qiluonang Kui Tang combined with Xelox regimen in the treatment of metastatic colorectal cancer has better clinical efficacy, can improve the quality of life of patients and reduce chemotherapy side effects.