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目的 探讨抗血管紧张素Ⅱ受体 1型 (angiotensinⅡtype 1 receptor ,ATR 1)自身抗体在妊高征发病中的作用。 方法 以合成的ATR 1多肽片段为抗原 ,采用酶联免疫吸附法检测 4 6例妊高征患者和 4 0例正常孕妇血清抗ATR 1自身抗体和血浆中血管紧张素Ⅱ的浓度。 结果 妊高征抗ATR 1自身抗体的阳性率为 6 3.0 % (2 9/46 ) ,明显高于正常孕妇 7.5 % (3/40 ) (P <0 .0 1)。妊高征组血浆血管紧张素Ⅱ水平 [(92 .5 4± 37.2 2 )pmol/L]亦明显高于血压正常组 [(2 5 .75± 12 .33)pmol/L ,P <0 .0 1]。 结论 妊高征患者合并血管紧张素Ⅱ浓度升高 ,其血清中存在抗ATR 1的自身抗体 ,该抗体可能在妊高征的发病机制中起重要作用。
Objective To investigate the role of anti-angiotensin Ⅱ type 1 receptor (ATR 1) autoantibodies in the pathogenesis of PIH. Methods The ATR 1 peptide fragments were used as antigen. The serum levels of anti-ATR 1 autoantibodies and plasma concentrations of angiotensin Ⅱ were detected by enzyme-linked immunosorbent assay in 46 cases of PIH and 40 cases of normal pregnant women. Results The positive rate of anti-ATR1 autoantibody against pregnancy-induced hypertension was 6 3.0% (29/46), which was significantly higher than that of normal pregnant women (3/40) (P <0.01). The level of plasma angiotensin Ⅱ in the PIH group was also significantly higher than that in the normotensive group [(92.5 ± 37.2 2) pmol / L, P <0.05). 0 1]. Conclusions Patients with PIH have elevated concentrations of angiotensin Ⅱ, and autoantibodies against ATR 1 exist in serum. This antibody may play an important role in the pathogenesis of PIH.