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目的研究驱铅治疗患者尿中总锌的含量及变化,为对症治疗提供科学依据。方法选择2012年1月—2013年4月进行驱铅治疗的35名患者作为研究对象,采集其24 h空白尿及不同治疗阶段的试排尿进行尿铅和尿锌含量的分析。结果比较24 h空白尿,男女尿铅含量差异无统计学意义(P>0.05),男性尿锌含量高于女性,差异有统计学意义(P<0.01)。轻度铅中毒的患者与铅吸收观察对象的空白尿锌含量间差异无统计学意义(P>0.05)。尿锌含量与年龄不存在相关关系(P>0.05),与尿铅含量存在不密切的正相关(r=0.429,P<0.05);第1疗程第1、第2、第3针后的尿锌含量显著高于空白尿,差异有统计学意义(P<0.01);第1、第2针排出的尿铅与尿锌不存在相关性(P>0.05),而第3针后两者存在显著的正相关关系(r=0.667,P<0.01)。空白尿锌与试排各个阶段的尿锌间均不存在相关关系(P>0.05)。结论使用依地酸二钠钙进行驱铅治疗的患者尿中排出大量的锌,疗程后期尿锌会随铅排出的增加而增加,所以在治疗的过程中,尤其是在疗程后期要特别注意微量元素丢失出现的不良反应,及时对症治疗。
Objective To study the content and changes of urinary total zinc in patients treated with lead-removing therapy and provide a scientific basis for symptomatic treatment. Methods A total of 35 patients with lead-removing therapy from January 2012 to April 2013 were enrolled in this study. Their urinary lead and urinary zinc were collected from 24-hour blank urine test and urination tests at different treatment stages. Results There was no significant difference in urinary lead levels between men and women in 24 h blank urine (P> 0.05). Urine zinc content in male was higher than that in female (P <0.01). There was no significant difference between the patients with mild lead poisoning and the blank urine zinc content of lead absorption observation subjects (P> 0.05). There was no correlation between urinary zinc and age (P> 0.05), and there was a positive correlation between urinary zinc and urinary lead (r = 0.429, P <0.05). Urinary zinc after 1, 2 and 3 (P <0.01). There was no correlation between urinary lead excreted in the first and the second needle and urine zinc (P> 0.05), but the third and the third needle Significant positive correlation (r = 0.667, P <0.01). There was no correlation between blank urine zinc and urinary zinc in each stage (P> 0.05). Conclusion Calcium disodium edetate excreted a large amount of zinc in the urine of patients with urinary lead excretion, urine zinc increased with the increase of lead excretion during the course of treatment, so in the course of treatment, especially in the late course of treatment should pay special attention to trace Adverse effects of elemental loss, timely symptomatic treatment.