选择有效的化疗药物是肿瘤化疗成功的关键，本研究以人甲状腺未分化癌细胞系ＴＡ－Ｋ为研究对象，利用 ＭＴＴ比色法进行了 ８种化疗药物的敏感性试验，以药物半数抑制浓度（ＩＣ５０）进行评价。ＴＡ－Ｋ对抗癌药物敏感性由高至低依次为长春新碱、顺铂、米托蒽醌、平阳霉素、阿霉素、足叶乙甙、氟尿嘧啶，环磷酰胺体外无效。此结果为甲状腺未分化癌治疗的实验研究和临床化疗方案的制定提供了参考依据。 The selection of effective chemotherapeutic agents is the key to the success of cancer chemotherapy. In this study, human anaplastic thyroid cancer cell line TA-K was used as the study object. MTT colorimetric assay was used to test the sensitivity of 8 chemotherapeutic drugs. (IC50) for evaluation. TA-K anticancer drug sensitivity from high to low followed by vincristine, cisplatin, mitoxantrone, pingyangmycin, doxorubicin, etoposide, fluorouracil, cyclophosphamide in vitro invalid. This result provides a reference for the experimental study of the treatment of anaplastic thyroid cancer and the development of a clinical chemotherapy protocol.