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本文对比观察了亚硒酸钠、透明质酸酶及山莨菪碱(654—2)对大鼠实验性心肌梗塞急性期(3天)时梗塞范围(IS)和左心室舒缩性能的影响。发现(1)亚硒酸钠无论在冠脉结扎术前或术后给药,均可显著缩小IS,其效果与透明质酸酶和654—2基本相同,(2)在缩小IS的同时,亚硒酸钠可显著改善左心室收缩及舒张性能,而其他两种药物则无此作用。结果提示亚硒酸钠对急性心肌梗塞的疗效优于透明质酸酶及654—2。此外,测定了大鼠心肌梗塞后血浆和心肌中的硒含量。
This article compared the effects of sodium selenite, hyaluronidase and anisodamine (654-2) on infarct size (IS) and left ventricular systolic and diastolic function in experimental acute myocardial infarction (3 days) in rats. It was found that (1) Sodium selenite could significantly reduce IS regardless of administration before or after coronary artery ligation, and its effect was basically the same as that of hyaluronidase and 654-2. (2) While reducing IS, Sodium selenite can significantly improve left ventricular systolic and diastolic performance, while the other two drugs have no such effect. The results suggest that sodium selenite is superior to hyaluronidase and 654-2 in the treatment of acute myocardial infarction. In addition, selenium levels in plasma and myocardium were determined after myocardial infarction in rats.