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目的研究代谢综合征(MS)对于原发性高血压(EH)患者靶器官损害的影响。方法入选不并发其他心血管及肾脏临床疾病的中老年EH患者153例,测定其血压、血脂、血糖等,计算BMI。所有患者接受超声心动图及颈动脉超声检查,计算左室质量指数(LVMI),区分有无左心室肥厚(LVH)。测量颈动脉内膜厚度并测定晨尿白蛋白浓度。结果并发MS的EH患者BMI、空腹血糖、TG、24h血压更高,HDL-C更低,发生LVH、微量白蛋白尿(MAU),颈动脉内膜增厚(IMT)或斑块形成的比例皆显著高于无MS的患者。结论EH患者并发MS,意味着心肾血管等靶器管的损害及心血管疾病危险性显著增加。
Objective To study the effect of metabolic syndrome (MS) on target organ damage in patients with essential hypertension (EH). Methods 153 middle-aged and elderly patients with EH who were not complicated by other cardiovascular and renal diseases were enrolled in the study. Blood pressure, blood lipids and blood glucose were measured to calculate BMI. All patients underwent echocardiography and carotid ultrasonography. Left ventricular mass index (LVMI) was calculated and left ventricular hypertrophy (LVH) was assessed. Carotid intima-media thickness was measured and morning urine albumin concentration was measured. Results In patients with MS complicated with MS, the BMI, fasting blood glucose, TG, blood pressure higher in 24h, lower HDL-C, incidence of LVH, MAU, IMT or plaque formation All patients were significantly higher than those without MS. Conclusions EH patients complicated with MS, which means that the heart and kidney vascular target tube damage and cardiovascular disease risk increased significantly.