目的：阐明手性药物相互作用的概念及其研究的临床意义。方法：综述近几年手性药物相互作用的研究状况和研究方法。结果：一些消旋体药物的对映体与对映体、对映体与其它并用药物之间在药效学或药动学上发生了相互作用。其中有些手性相互作用在临床上被视为是有益的，有些则引起药物不良反应。遗传多态性和年龄相关性在手性相互作用中也有发生。结论：手性药物相互作用的研究能更深入地理解或积极地预期一些药物相互作用，为临床合理用药提供依据。 Objective: To clarify the concept of chiral drug interactions and its clinical significance. Methods: The research status and research methods of chiral drug interactions in recent years were reviewed. RESULTS: The enantiomeric, enantiomeric and enantiomeric interactions of some racemic drugs interacted pharmacodynamically or pharmacologically. Some of these chiral interactions are clinically considered beneficial, while others cause adverse drug reactions. Genetic polymorphisms and age-related interactions also occur in chiral interactions. Conclusion: The study of chiral drug interactions can better understand or positively predict the interaction of some drugs and provide a basis for clinical rational drug use.