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目的:观察生长抑素治疗急性胰腺炎的疗效及其抗炎作用。方法:急性胰腺炎患者52例随机分为对照组和观察组,对照组给予生长抑素等综合治疗,观察组给予生长抑素联合大黄治疗。观察两组腹胀和腹痛消失时间、首次自主排气排便时间及平均住院日。观察两组治疗第1,3,5,7天血浆的肿瘤坏死因子-α(Tumor necrosis factor alpha,TNF-α)、白细胞介素6(nterleukin 6,IL-6)、c反应蛋白(C-reactive protein,CRP)水平,并进行比较。结果:观察组腹胀和腹痛消失时间、首次自主排气排便时间及平均住院时间均短于对照组。观察组TNF-α在第5,7天明显低于对照组;IL-6和CRP在治疗第5天明显低于对照组。结论:生长抑素联合大黄治疗急性胰腺炎疗效显著,可以有效降低急性胰腺炎患者炎性因子TNF-α、IL-6、CPR水平,值得临床推广。
Objective: To observe the effect of somatostatin on acute pancreatitis and its anti-inflammatory effect. Methods: Fifty-two patients with acute pancreatitis were randomly divided into control group and observation group. The control group was given somatostatin and other combined treatment. The observation group was given somatostatin combined with rhubarb treatment. Observe the two groups of abdominal distension and abdominal pain disappear time, the first time of spontaneous discharge defecation and the average length of stay. The plasma levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and c-reactive protein (C- reactive protein (CRP) levels, and compared. Results: The disappearance time of abdominal distension and abdominal pain in the observation group was shorter than that of the control group for the first time of spontaneous excretion and defecation. The levels of TNF-α in the observation group were significantly lower than those in the control group on the 5th and 7th days. The levels of IL-6 and CRP in the observation group were significantly lower than those of the control group on the 5th day. Conclusion: The combination of somatostatin and rhubarb is effective in the treatment of acute pancreatitis, which can effectively reduce the levels of inflammatory cytokines TNF-α, IL-6 and CPR in patients with acute pancreatitis and is worthy of clinical promotion.