复习近年来的相关文献 ,综述前列腺特异性抗原 (PSA )在乳腺癌的研究近况。PSA是具有胰蛋白酶和糜蛋白酶活性的一种丝氨酸糖蛋白酶 ,并非前列腺特有。编码PSA的基因是人腺体激肽释放酶基因家族成员之一。它不仅是判断乳腺癌患者预后的一个新的指标 ,而且对其研究可洞察乳腺癌组织中甾体类受体状况以预测辅助治疗的效果。 Review the literature in recent years, review of prostate-specific antigen (PSA) in breast cancer research. PSA is a serine protease with trypsin and chymotrypsin activity and is not unique to the prostate. The gene encoding PSA is a member of the human glandular kallikrein gene family. It is not only a new indicator of the prognosis of breast cancer patients, but also its research can be insight into the status of steroid receptors in breast cancer tissue to predict the effect of adjuvant therapy.