Through embryo culture, intergeneric hybrids were produced between common wheat,Triticum aestivum cv. Chinese Spring (CS) (2n= 6x = 42, AABBDD) and crested wheatgrass,Agropyron desertorum (2n =4x =28, PPPP) for the first time. Their F_2 and BC_1 seeds havealso been successfully obtained by selfing and backcrossing with wheat in F_1 hybrids. Theseedlings of all F_1 hybrids tended to resemble their female parent, but they had more tillers,and their spike characteristics were between their parents. Average meiotic chromosomepairing at MI of F_1 hybrids was: 6.62Ⅰ+ 8.20RingⅡ+ 4.16RodⅡ+0.57Ⅲ+ 0.35Ⅳ+0.06Ⅴ+0.03Ⅵ. The successful experience of hybridization of common wheat with A. desertorum,the reason for the high level of chromosome pairing and self-fertility in the F_1 hybrids werediscussed. The F_2 and BC_1 seeds obtained in F_1 hybrids are of great importance to theory andpractice. Through embryo culture, intergeneric hybrids were produced between common wheat and Triticum aestivum cv. Chinese Spring (CS) (2n = 6x = 42, AABBDD) and crested wheatgrass, Agropyron desertorum (2n = 4x = 28, PPPP) Their F_2 and BC_1 seeds have been successfully obtained by selfing and backcrossing with wheat in F_1 hybrids. These are all F_1 hybrids tended to resemble their female parent, but they had more tillers, and their spike characteristics were between their parents. Average meiotic chromosomepairing at MI of F_1 hybrids was: 6.62 I + 8.20 RING II + 4.16 Rod II + 0.57 III + 0.35 IV + 0.06 V + 0.03 VI. The successful experience of hybridization of common wheat with A. desertorum, the reason for the high level of chromosome pairing and self-fertility in the F_1 hybrids werediscussed. The F_2 and BC_1 seeds obtained in F_1 hybrids are of great importance to theory and practice.