Triterpenoids and phenolics from the fruiting bodies of Inonotus hispidus and their activations of m

来源 :Chinese Chemical Letters | 被引量 : 0次 | 上传用户:C263185
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Two new 24-methyl lanostane triterpenoids,hispindic acids A and B(1 and 2),and a new phenolic compound,hispinine(7),along with nine known compounds(3-6,and 8-12),were isolated from the fruiting bodies of Inonotus hispidus.Their structures were elucidated based on the extensive analysis of spectroscopic data(NMR and HRMS).Hispindic acid A(1) possesses an unusual formyl group at C-30.Compounds 1,3-4,and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control,8-methoxypsoralen,at 50 μmol/L Two new 24-methyl lanostane triterpenoids, hispindic acids A and B (1 and 2), and a new phenolic compound, hispinine (7), along with nine known compounds (3-6, and 8-12), were isolated from the fruiting bodies of Inonotus hispidus. Their structures were elucidated based on the extensive analysis of spectroscopic data (NMR and HRMS). Hispindic acid A (1) possesses an unusual formyl group at C-30.Compounds 1,3-4, and 8 showed stronger activate abilities of melanogenesis and tyrosinase in B16 melanoma cells than those of positive control, 8-methoxypsoralen, at 50 μmol / L
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