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目的评价2种治疗方案对重度外阴阴道假丝酵母菌病患者的临床疗效。方法将150例重度外阴阴道假丝酵母菌病患者分为A组:口服氟康唑150mg/d,连续3d,同时硝酸咪康唑阴道软胶囊阴道局部使用,1200mg/次,1次/3d,2d疗法。B组:先用A组方法,之后在月经干净后硝酸咪康唑阴道软胶囊1200mg阴道局部使用,连续用药3个月经周期。疗程结束后比较两组临床疗效、真菌检查结果、患者满意度。结果近期临床疗效及真菌检查,两组间差异无统计学意义(P>0.05)。远期疗效B组优于A组,差异有统计学意义(P<0.05)。满意度比较A组患者的优于B组,差异有统计学意义(P<0.05)。结论口服氟康唑配合硝酸咪康唑阴道软胶囊阴道局部延长应用的优化治疗方案,能够提高显著提高重度外阴阴道假丝酵母菌病患者远期疗效,减少复发率,值得临床推广。
Objective To evaluate the clinical effects of two kinds of treatment on patients with severe vulvovaginal candidiasis. Methods 150 patients with severe vulvovaginal candidiasis were divided into group A: oral fluconazole 150mg / d, continuous 3d, while miconazole nitrate vaginal soft vaginal vaginal use, 1200mg / time, 1 / 3d, 2d therapy. Group B: first with Group A method, followed by clean menstrual miconazole nitrate vaginal soft capsule vaginal 1200mg vaginal use, continuous medication 3 menstrual cycle. After the end of treatment, the clinical efficacy, fungal test results and patient satisfaction were compared between the two groups. Results of recent clinical efficacy and fungal examination, the difference between the two groups was not statistically significant (P> 0.05). Long-term efficacy of group B is better than group A, the difference was statistically significant (P <0.05). The satisfaction of patients in group A was better than that in group B, the difference was statistically significant (P <0.05). Conclusion The optimized treatment of oral fluconazole combined with miconazole nitrate vaginal soft capsule vaginal application can improve the long-term efficacy and reduce the recurrence rate of patients with severe vulvovaginal candidiasis, which is worthy of clinical promotion.