子痫前期(preeclampsia,PE)是妊娠期妇女特有的疾病,发病率高达3%,常伴有严重的母婴并发症,是导致孕妇死亡的主要原因[1]。子痫前期是以妊娠中期出现高血压和蛋白尿为特征,分为早发型(34周之前)和晚发型(34周后)子痫前期[2]。子痫前期的发病机制迄今尚未完全阐明,目前认为该病始发于妊娠早期,引起胎盘血管发育障碍,导致胎盘的浅着床、氧化应激及系统性炎症反 Preeclampsia (PE) is a peculiar disease of pregnant women, the incidence of up to 3%, often accompanied by serious maternal and infant complications, is the leading cause of maternal death [1]. Pre-eclampsia is characterized by high blood pressure and proteinuria during the second trimester of pregnancy and is classified as early-onset (34 weeks) and late-onset (34 weeks) preeclampsia [2]. The pathogenesis of preeclampsia has not been fully elucidated so far, the disease is currently believed that the disease occurs in early pregnancy, causing placental vascular dysplasia, resulting in aplacenta placenta, oxidative stress and systemic inflammation