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将加味小金丹酊剂外敷小鼠和大鼠脱毛表皮,用同位素示踪技术测定其有效成分——马钱子碱在小鼠尿液中的排泄量和大鼠中的血药浓度。实验结果表明,马钱子碱在尿液中的排泄量为6.892μg/(cm~2·h),其最大血药浓度为51.81ng/me。
External epidermal peels of mice and rats were treated with flavored Xiaojindan tincture. The effective components of strychnine in mice’s urine and blood concentration in rats were determined by isotope tracer techniques. The experimental results showed that the excretion amount of strychnine in urine was 6.892μg/(cm~2·h), and the maximum plasma concentration was 51.81ng/me.