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目的:观察心康冲剂对慢性心力衰竭大鼠血浆肾素-血管紧张素-醛固酮系统(RAAS)的影响。方法:70只SD大鼠随机抽取10只为正常对照组,剩余大鼠腹腔注射阿霉素建立慢性心力衰竭模型,再随机分为模型对照组、芪苈强心组、心康冲剂低、中、高剂量组,每组各12只。分别给药,给药6周后,每组取存活大鼠6只用酶联免疫法检测血浆PRA、AngⅡ、ALD水平。结果:与正常组比较,模型组血浆PRA、AngⅡ、ALD水平均显著升高(P<0.05),证明造模成功;与模型组比较,芪苈强心组、心康冲剂各组血浆PRA、AngⅡ、ALD水平均降低,差异有统计学意义(P<0.05);与芪苈强心组比较,心康冲剂各组血浆PRA、AngⅡ、ALD水平差异均无统计学意义(P>0.05);心康冲剂各组间血浆PRA、AngⅡ、ALD水平比较,差异无统计学意义(P>0.05)。结论:心康冲剂通过降低心衰大鼠血浆PRA、AngⅡ、ALD水平,抑制RAAS过度激活。
Objective: To observe the effect of xinkang granules on plasma renin - angiotensin - aldosterone system (RAAS) in rats with chronic heart failure. Methods: Seventy SD rats were randomly selected as the normal control group. The remaining rats were injected intraperitoneally with doxorubicin to establish a model of chronic heart failure, and then randomly divided into model control group, Qiqiangqiangxin group, Xinkang granules low, medium , High-dose group, each group of 12. Were given separately. Six weeks after the administration, 6 rats in each group were tested for plasma PRA, AngⅡ, ALD levels by enzyme-linked immunosorbent assay. Results: Compared with the normal group, the levels of plasma PRA, AngⅡ and ALD in the model group were significantly increased (P <0.05), which proved successful in modeling. Compared with the model group, the plasma PRA, (P <0.05). Compared with Qiliqiangqiangxin group, there was no significant difference in plasma PRA, AngⅡand ALD levels among all groups (P> 0.05). There was no significant difference in the levels of PRA, AngⅡ and ALD between the two groups (P> 0.05). Conclusion: Xinkang Granule can inhibit the over-activation of RAAS by decreasing the plasma levels of PRA, AngⅡ and ALD in heart failure rats.