Particle radiation therapy is an exciting area of radiotherapy basic and clinical researches.The majority of particle radiotherapy work is being done with proton beams having essentially the same radiobiologic properties as conventional photon/electron radiation but allowing a much more precise control of the radiation dose distribution.However,other charged particles are also playing an increasing role,like neutrons.In this review article we will summarize the data related to basic and clinical experiences related to particle beam radiation therapy. Particle radiation therapy is an exciting area of ​​radiotherapy basic and clinical researches. The majority of particle radiotherapy work is being done with proton beams having essentially the same radiobiologic properties as conventional photon / electron radiation but allowing a much more precise control of the radiation dose distribution .However, other charged particles are also playing an increasing role, like neutrons. This review article we will summarize the data related to basic and clinical experiences related to particle beam radiation therapy.