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目的 :探讨内皮素 (ET)和一氧化氮 (NO)在妊高征时的致病机理。方法 :用放免法测定ET ;硝酸根还原酶法结合Griess法测定NO的稳定代谢产物亚硝酸基 /硝酸基 (NO-2 /NO-3 )含量。对 2 6例妊高征患者 (PIH)和 30例同期住院的正常晚期妊娠妇女的外周血ET和NO进行了研究。结果 :PIH患者与正常晚期妊娠妇女比较 ,产前外周血中ET水平显著升高 ,NO-2 /NO-3 水平显著降低 (P <0 0 1) ,随着PIH病情的加重 ,ET逐渐升高 ,NO-2 /NO-3 逐渐降低。正常晚期妊娠妇女血NO-2 /NO-3 水平与ET水平呈显著正相关 (r=0 .37,P <0 0 5 ) ,PIH患者NO-2 /NO-3 水平与ET水平呈显著负相关 (r=- 0 .42 ,P <0 0 5 )。结论 :NO合成的减少 ,ET合成增加 ,ET与NO平衡失调 ,可能是妊高征发病过程中的一个重要环节。
Objective: To investigate the pathogenesis of endothelin (ET) and nitric oxide (NO) during pregnancy induced hypertension. Methods: ET was determined by radioimmunoassay (RIA). The content of nitrite / nitrite (NO-2 / NO-3), a stable metabolite of NO, was determined by nitrate reductase method and Griess method. Peripheral blood ET and NO were studied in 26 PIH patients and 30 normal late pregnant women hospitalized in the same period. Results: Compared with normal pregnant women, the ET level in prenatal peripheral blood was significantly increased and the NO-2 / NO-3 level was significantly lower in PIH patients (P <0.01). With the progression of PIH, ET gradually increased High, NO-2 / NO-3 gradually decreased. NO-2 / NO-3 levels were positively correlated with ET level in normal pregnant women (r = 0.37, P <0 05), NO-2 / NO-3 levels and ET levels were significantly negative in PIH patients (R = - 0.42, P <0 0 5). Conclusion: The decrease of NO synthesis, the increase of ET synthesis and the imbalance of ET and NO may be an important link in the pathogenesis of PIH.