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目的通过对妊娠中晚期产前诊断指征,及对产前筛查高风险胎儿进行脐血染色体核型分析,探讨胎儿脐血染色体分析在产前诊断中的应用价值。方法对2010年1月—2012年12月于我院就诊的441例具有产前诊断指征的孕妇,在B超引导下行脐带穿刺术,取脐血细胞培养,染色体制备及胎儿染色体核型分析。结果在441例产前诊断孕妇中,共检出异常核型49例,包括染色体数目异常23例,结构异常26例,胎儿染色体异常率为11.11%。结论脐血细胞培养染色体核型分析,为胎儿染色体异常临床诊断提供了可靠依据,在产前诊断中具有重要的作用。
Objective To investigate the indications of prenatal diagnosis in the second trimester of pregnancy and to analyze the karyotype of umbilical blood karyotype in prenatal screening high risk fetus to explore the value of fetal umbilical blood chromosome analysis in prenatal diagnosis. Methods From January 2010 to December 2012, 441 pregnant women with prenatal diagnosis indications in our hospital underwent ultrasound-guided umbilical cord puncture, cord blood cell culture, chromosome preparation and fetal karyotype analysis. Results In 441 prenatal diagnosis of pregnant women, a total of 49 cases of abnormal karyotype were detected, including 23 cases of chromosomal abnormalities, 26 cases of structural abnormalities and 11.11% of fetal chromosomal abnormalities. Conclusion The karyotype analysis of cord blood cell culture provides a reliable basis for the clinical diagnosis of fetal chromosomal abnormalities and plays an important role in prenatal diagnosis.