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目的研究环氧合酶-2(Cyclooxygenase-2,COX-2)在宫颈鳞状细胞癌中的表达及对预后的影响。方法选择2008年6月—2009年10月在邯郸市第一医院和中心医院住院治疗的原发宫颈鳞癌患者77例,采用免疫组化S-P法,检测COX-2在宫颈鳞癌中的表达情况及其与预后的关系。结果 COX-2在77例宫颈鳞癌中的阳性表达率为68.8%(53/77),单因素分析显示COX-2的表达与宫颈癌的生存率无关(P>0.05),多因素分析发现:COX-2与组织学分级、临床分期、淋巴结转移、宫旁或脉管浸润及肌层浸润深度为宫颈鳞癌预后的危险因素(P<0.05)。患者的5年生存率为74.03%,生存时间最短8.6个月,最长62个月。结论 COX-2为宫颈鳞癌的独立预后因素,对判断预后及指导治疗具有重要的临床价值。
Objective To study the expression of Cyclooxygenase-2 (COX-2) in cervical squamous cell carcinoma and its prognosis. Methods Seventy-seven patients with primary cervical squamous cell carcinoma hospitalized in the First Hospital and Central Hospital of Handan from June 2008 to October 2009 were enrolled in this study. The expression of COX-2 in cervical squamous cell carcinoma was detected by immunohistochemical SP method Situation and its relationship with prognosis. Results The positive rate of COX-2 in cervical squamous cell carcinoma was 68.8% (53/77). Univariate analysis showed that the expression of COX-2 had no correlation with the survival rate of cervical cancer (P> 0.05). Multivariate analysis The risk factors for the prognosis of cervical squamous cell carcinoma were the COX-2 and histological grade, clinical stage, lymph node metastasis, uterine or vascular invasion and the depth of myometrial invasion (P <0.05). The 5-year survival rate of patients was 74.03%, the shortest survival time was 8.6 months and the longest was 62 months. Conclusion COX-2 is an independent prognostic factor for cervical squamous cell carcinoma and has important clinical value in judging prognosis and guiding treatment.