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组织型纤维蛋白溶酶原激活剂(t-PA)系从黑色素瘤细胞培养液中的提取与纯化,极为费力与价贵。为此,应用 DNA 重组技术在大肠杆菌中克隆和表达人体 t-PA 基因,以大规模生产 t-PA。本文报道静脉给予基因重组产生的 t-PA(rt-PA)对实验性冠状动脉血栓狗进行溶解血栓的试验。
Tissue-type plasminogen activator (t-PA) from melanoma cell culture medium in the extraction and purification, very laborious and expensive. For this purpose, human t-PA gene was cloned and expressed in E. coli using DNA recombination technology to produce t-PA on a large scale. This article reports the intravenous administration of genetically modified t-PA (rt-PA) on experimental coronary thrombosis in dogs thrombolytic test.