哌仑西平ig能抑制大鼠吲哚美辛、利血平、应激性和幽门结扎胃溃疡及半胱胺十二指肠溃疡的形成,促进醋酸胃溃疡愈合.哌仑西平对胃酸、胃蛋白酶分泌有明显的抑制作用.还增加[~3H]TdR参入胃粘膜细胞DNA量和促进胃粘液合成.因此,除胃酸、胃蛋白酶分泌抑制外,胃粘膜屏障作用的增强也与其抗溃疡作用有关. Pirenzepine can inhibit indometacin, reserpine, stress and pylorus ligation of gastric ulcer and cysteamine duodenal ulcer formation, promote the healing of gastric ulcer.Pirenzepine on gastric acid, stomach Protease secretion, but also increase the [~ 3H] TdR into the gastric mucosal cells and promote gastric mucosal DNA synthesis.Therefore, in addition to gastric acid, inhibition of pepsin secretion, the role of gastric mucosal barrier is also enhanced with its anti-ulcer effect .