人工抗原提呈细胞的制备原理是模拟T细胞活化的双重信号机制,在一定的载体表面展现抗原肽-MHC分子复合物及共刺激分子、黏附分子的配体或抗体构建而成。它能有效活化和扩增抗原特异性T细胞,而且效率高、可行性好。人工抗原提呈细胞不仅对肿瘤的免疫治疗具有重要价值,而且还可用于抗原表位的筛选、效应细胞的检测及T细胞活化信号的研究。本文就人工抗原提呈细胞的研究进展作一综述。 The preparation principle of artificial antigen presenting cells is a dual signal mechanism that simulates the activation of T cells, and is constructed by displaying antigen peptide-MHC molecular complexes and co-stimulatory molecules, adhesion molecule ligands or antibodies on a certain carrier surface. It can effectively activate and expand antigen-specific T cells with high efficiency and good feasibility. Artificial antigen presenting cells not only has important value for the immunotherapy of tumors, but also can be used for the screening of antigenic epitopes, the detection of effector cells and the study of T cell activation signals. This article reviews the progress of research on artificial antigen presenting cells.