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目的:研究PTPN13和FAK在肺鳞癌中的表达及意义,为建立早期预防、早期诊断、预后预警及个体化治疗的肺鳞癌防治新策略奠定基础。方法:免疫组化法观察PTPN13及FAK在肺鳞癌及癌旁组织中的表达情况。结果:PTPN13表达与肺鳞癌的临床分期、组织分化程度及淋巴结转移呈显著负相关(P<0.05);FAK表达与肺鳞癌的临床分期、组织分化程度及淋巴结转移呈显著正相关(P<0.05);PTPN13和FAK在肺鳞癌组织中的表达呈显著负相关(P<0.05)。结论:PTPN13基因是肺鳞癌发生相关的抑癌基因,其抑制肿瘤侵袭转移的生物学功能可能与FAK磷酸化有关。
Objective: To study the expression and significance of PTPN13 and FAK in squamous cell carcinoma of the lung, and to lay a foundation for the establishment of a new strategy for prevention and treatment of squamous cell carcinoma of lung squamous cell carcinoma in early prevention, early diagnosis, early warning and individualized treatment. Methods: Immunohistochemistry was used to observe the expression of PTPN13 and FAK in lung squamous cell carcinoma and adjacent tissues. Results: There was a significant negative correlation between the expression of PTPN13 and clinical stage, histological grade and lymph node metastasis (P <0.05). The expression of FAK in lung squamous cell carcinoma was significantly correlated with the clinical stages, histological grade and lymph node metastasis <0.05). There was a significant negative correlation between the expression of PTPN13 and FAK in lung squamous cell carcinoma (P <0.05). Conclusion: PTPN13 gene is a tumor suppressor gene associated with lung squamous cell carcinoma. The biological function of PTPN13 gene in inhibiting tumor invasion and metastasis may be related to FAK phosphorylation.