对羟基苯甲酸酯类化合物通常用作防腐剂,主要应用于个人护理产品、药品和食品领域。它的广泛使用使其在环境中无处不在,随着相关研究的深入,越来越多的证据表明其可能具有潜在内分泌干扰效应,从而影响到生殖系统以及对类固醇敏感组织的相应功能,并且可能与乳腺癌的发生有关。本文对羟基苯甲酸酯类的使用、环境分布及其潜在的内分泌干扰效应和可能参与的肿瘤形成过程进行概述。 Parabens are commonly used as preservatives and are mainly used in personal care products, pharmaceuticals and foodstuffs. Its widespread use makes it ubiquitous in the environment. With the deepening of related research, more and more evidences indicate that it may have potential endocrine disrupting effect, thus affecting the reproductive system and the corresponding function of steroid-sensitive tissues, and May be related to the occurrence of breast cancer. This article provides an overview of the use of hydroxybenzoates, their environmental distribution and their potential endocrine disrupting effects and possible involvement in tumorigenesis.