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目的:阐明重症失血时白介素-J(IL-1)、白介素-6(IL-6)和肿瘤坏死因子(TNF-α)活性的变化,探讨失血及其休克免疫调节机制。方法:采用放射免疫分析法对47例重症失血和15例正常对照进行血清1L-1、IL-6和TNF-α活性检测。结果:全组IL-1、IL-6和TNF-α活性较对照组明显增高(P<0.001),休克组较未休克组增高明显(P<0.001),内、外科组间比较无差异(P>0.05),1L-1、IL-6与TNF-α活性正相关(r=0.78,P<0.01)。结论:出血引起免疫变化,1L-1、IL-6和TNF-α介入出血及其休克的发生、发展,此可能作为判断病情和疗效的一种指标。
Objective: To elucidate the changes of interleukin-1, interleukin-6 and tumor necrosis factor-α (TNF-α) in patients with severe blood loss and to explore the mechanism of hemorrhagic shock and its immune regulation. Methods: Serum 1L-1, IL-6 and TNF-α were detected by radioimmunoassay in 47 cases of severe blood loss and 15 cases of normal control. Results: Compared with the control group, the activity of IL-1, IL-6 and TNF-α in the whole group was significantly increased (P <0.001), while in the shock group was significantly higher than that in the non-shock group (P <0.001) P> 0.05). There was a positive correlation between the levels of IL-6 and TNF-α (r = 0.78, P <0.01). CONCLUSION: Hemorrhage may cause immune changes. The occurrence and development of hemorrhage and hemorrhage involving 1L-1, IL-6 and TNF-α may be involved in the development of hemorrhage, which may be used as an indicator of disease severity and efficacy.