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创伤或脓毒症合并急性肺功能衰竭者,肺动脉压往往增高,其病因较多,部分病因能用血管扩张药逆转。作者将硝普盐(Np)及硝酸甘油(Ng)治疗此类病人,并研究这些药物对肺血液动力学及气体交换的作用。11例呼吸机能不全者,平均肺动脉压大于19Torr,肺分流大于13.5％。包括3例多发性创伤,3例上胃肠道大出血紧急手术,5例腹内脓毒症者。均行气管内插管,机械正压换气,肺动脉及外周动脉插管。给药前测墓础数据、包括平均动脉压(MAP)、平均肺动脉压(MPAP)、肺楔压(PWP)、心输出量、吸入气、呼出气、动脉血和混合静脉
Trauma or sepsis with acute pulmonary failure, pulmonary arterial pressure is often increased, its causes more, some of the causes can be reversed with vasodilator drugs. The authors treated patients with nitroprusside (Np) and nitroglycerin (Ng) and investigated the effects of these drugs on pulmonary hemodynamics and gas exchange. Eleven cases of respiratory insufficiency, the average pulmonary artery pressure greater than 19Torr, pulmonary shunt greater than 13.5%. Including 3 cases of multiple trauma, 3 cases of upper gastrointestinal bleeding emergency surgery, 5 cases of intra-abdominal sepsis. All tracheal intubation, mechanical positive pressure ventilation, pulmonary artery and peripheral arterial catheterization. Pretreatment tomographic data including mean arterial pressure (MAP), mean pulmonary arterial pressure (MPAP), pulmonary wedge pressure (PWP), cardiac output, inspiration, exhaled breath, arterial blood and mixed veins