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应用放射免疫法测定１５例妊高征患者，１５例正常妊娠妇女母血和脐血中心钠素与内皮素含量。结果：妊高征组母血和脐血中心钠素均明显高于正常妊娠组（Ｐ＜０．０１），妊高征组母血中内皮素明显高于正常妊娠组（Ｐ＜０．０１），而两组脐血内皮素无明显差别（Ｐ＞０．０５），各组心钠素与内皮素之间均有明显正相关（Ｐ＜０．０１）。说明内皮素在妊高征发病中起重要作用。而心钠素在抑制妊高征发生中应起一定作用；心钠素与内皮素之间相互影响。
Radioimmunoassay was used to determine the contents of atrial natriuretic peptide and endothelin in maternal blood and umbilical cord blood in 15 patients with PIH and 15 normal pregnant women. Results: The plasma sodium and atrial natriuretic peptide in PIH group were significantly higher than those in normal pregnancy group (P <0.01). The ET in the PIH group was significantly higher than that in the normal pregnancy group (P <0.01) ), While there was no significant difference between the two groups (P> 0.05). There was a significant positive correlation between atrial natriuretic peptide and endothelin (P <0.01). Endothelin in the pathogenesis of pregnancy induced hypertension play an important role. The atrial natriuretic peptide in the inhibition of pregnancy-induced hypertension should play a role; between atrial natriuretic peptide and endothelin affect each other.