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目的：检测淋巴结内非霍奇金淋巴瘤Ｐ５３蛋白的表达，探讨其意义。方法：常规ＨＥ染色进行组织学分类，利用免疫组织化学ＬＳＡＢ法确定肿瘤的免疫表型、检测淋巴瘤中Ｐ５３蛋白的表达水平。结果：６０例非霍奇金淋巴瘤中，Ｐ５３蛋白阳性３２例（５３．３％）。其中，低度恶性３８例，Ｐ５３蛋白阳性１８例（４７．４％）；高度恶性２２例，Ｐ５３蛋白阳性１４例（６３．６％）。１０例淋巴结反应性增生Ｐ５３蛋白均为阴性。结论：Ｐ５３蛋白的积聚在非霍奇金淋巴瘤的发生发展过程中可能起着一定作用；Ｐ５３蛋白表达的阳性程度及阳性率可能与非霍奇金淋巴瘤的恶性度有关；Ｐ５３蛋白在淋巴结反应性增生组织中不表达
Objective: To detect the expression of P53 protein in lymph node non-Hodgkin’s lymphoma and its significance. METHODS: HE staining was used for histological classification. The immunohistochemical LSAB method was used to determine the tumor’s immunophenotype and detect the expression of P53 protein in lymphoma. RESULTS: Among 60 non-Hodgkin’s lymphomas, 32 were P53 positive (53.3%). Among them, 38 cases were of low grade malignancy, 18 cases (47.4%) were positive for P53 protein, 22 cases were highly malignant, and 14 cases (63.6%) were positive for P53 protein. All 10 cases of lymph node reactive hyperplasia were negative for P53 protein. Conclusion: Accumulation of P53 protein may play a role in the development of non-Hodgkin’s lymphoma; The positive and positive rate of P53 protein expression may be related to the degree of malignancy of non-Hodgkin’s lymphoma; P53 protein in lymph nodes Reactive hyperplasia does not express